Life happens — and sometimes, it happens with a headache, a stuffy nose, or an upset stomach.

That’s why having a well-stocked medicine cabinet is essential.

Over-the-counter (OTC) medications can provide quick relief for common ailments and help you manage minor health concerns from the comfort of your home.

The best part? You can find over-the-counter medications — and more home health remedies — at your local community pharmacy.

Next time you stop by to stock up, then, here are the nine OTC medications that you should keep in mind.
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1. Pain Relievers

From tension headaches to sore muscles, pain relievers like acetaminophen (Tylenol) and ibuprofen (Advil) are staples in any medicine cabinet.

Acetaminophen is great for reducing fever and easing mild to moderate pain.

Ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), goes a step further by treating inflammation — making it ideal for aches caused by sprains, strains, or even arthritis.

Keep in mind that dosage matters.

Always follow the instructions on the label, and consult your pharmacist if you’re unsure about how to use these medications safely — especially if you have underlying health conditions.
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2. Antihistamines

If you find yourself struck with seasonal sniffles — or if you’re prone to unexpected allergic reactions — antihistamines like diphenhydramine (Benadryl) or loratadine (Claritin) are must-have medications.

Diphenhydramine works to relieve symptoms like itching, hives, or nasal congestion. A word of caution, though: It can cause drowsiness, so it’s often best taken at night.

For daytime use, try non-drowsy options like loratadine or cetirizine (Zyrtec).

Outside of allergies, antihistamines can also be lifesaving in cases of mild allergic reactions to foods, insect bites, or environmental triggers.

With so many uses, it’s best to keep a bottle or two on hand.
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3. Cold and Flu Medicine

In the colder months, colds and flu can hit when you least expect them.

Luckily, decongestants like pseudoephedrine or phenylephrine, cough suppressants like dextromethorphan (Robitussin), and expectorants like guaifenesin (Mucinex) can help you get back on your feet.

If, on the other hand, you struggle with nasal congestion, saline sprays or medicated sprays like oxymetazoline (Afrin) can provide quick relief.

Be mindful, though, not to overuse medicated sprays — as they can cause rebound congestion if used for more than three consecutive days.

For more cold and flu must-haves, check out our blog, 12 Essentials to Get from Your Pharmacy This Cold and Flu Season.
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4. Antacids

You know the feeling of a sour stomach after you have an extra slice of pizza, add a dash of hot sauce to your wings, or sprinkle certain spices on your food.

Heartburn, indigestion, or acid reflux can wreak havoc on your day.

Luckily, antacids like calcium carbonate (Tums) provide fast relief by neutralizing stomach acid, while acid reducers like ranitidine (Zantac) or famotidine (Pepcid) help control the production of acid over time.

If you regularly experience acid reflux, talk to your pharmacist about proton pump inhibitors (like omeprazole) — which are available over the counter and with a prescription.

In any case, having antacids handy can make a world of difference when indigestion strikes after a big meal.
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5. Anti-Diarrheal Medication

Unfortunately, heartburn isn’t the only digestive problem you may face.

An upset stomach can come out of nowhere, but anti-diarrheal medications like loperamide (Imodium) can help slow down intestinal movement and relieve symptoms quickly.

While effective for short-term use, you should remember that anti-diarrheal medications are not a long-term solution.

If your symptoms persist or worsen, make sure you talk to a healthcare provider.

In the meantime, though, loperamide can help you ensure that stomach issues don’t interfere with your daily life — especially during travel or after an unexpected meal.
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6. Laxatives

On the flip side, constipation is another common issue that can benefit from OTC medications.

Laxatives like polyethylene glycol (MiraLAX) or stimulant options like bisacodyl (Dulcolax) help get things moving when your digestive system slows down.

Stool softeners like docusate sodium (Colace) are gentler options that can be useful for preventing constipation — especially after surgery or during pregnancy.

Keep these medications in your cabinet for when regular remedies — like increased water and fiber intake — aren’t quite enough.
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7. Antibiotic Ointment

Minor cuts, scrapes, and burns are inevitable — especially if you have kids or lead an active lifestyle.

A topical antibiotic ointment like Neosporin or bacitracin can help prevent infection and speed up the healing process.

Make it a habit to clean any wound thoroughly before applying the ointment and covering it with a clean bandage.

Having a few antibiotic ointments on hand ensures you’re ready to handle everyday injuries whenever they may come.

For more fool-proof tips for injury prevention, visit our blog, 12 Supplies for Your First Aid Kit.
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8. Hydrocortisone Cream

On that note, if time outside leaves you with itchy skin, rashes, or bug bites, hydrocortisone is a must-have medication to get fast relief.

This mild corticosteroid reduces inflammation and soothes itchiness, making it a useful solution for a variety of skin issues.

As with any OTC, though, hydrocortisone isn’t a permanent solution.

If you’re facing severe or persistent skin conditions, though, consult with your pharmacist or healthcare provider to explore your treatment options.
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9. Electrolyte Solutions

Staying hydrated is essential, but sometimes water alone isn’t enough.

Electrolyte solutions like Pedialyte, LiquidIV, or LMNT can help replenish lost fluids and electrolytes after a lengthy illness, a long workout, or daily dehydration.

They’re especially useful if you’re recovering from vomiting or diarrhea, which can throw off your hydration and electrolyte balance.

Keeping a small stash of electrolytes in your home ensures that you’re ready to handle hydration needs at a moment’s notice.
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Conclusion

A well-stocked medicine cabinet is your first line of defense against minor health hiccups.

From pain relievers to hydration solutions, these OTC medications can help you manage common ailments and keep your household healthy.

For more tips on taking OTC medications, visit our blog, How to Unlock the Power of Over-the-Counter Health Products.

And, for even more personalized advice, stop by your local pharmacy.

After all, building a good relationship with your pharmacist can make all the difference in your health journey.

Looking for a trusted pharmacy near you? Use our RxLocal Pharmacy Finder to find one and get the OTC items you need.